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Tesamorelin 5mg


Tesamorelin 5mg

Tesamorelin, also known as Egrifta, is a synthetic analogue of growth hormone-releasing hormone (GHRH). It is a 44-amino acid peptide that stimulates the production and release of growth hormone (GH) from the pituitary gland. Tesamorelin has been primarily investigated for its potential to reduce excess abdominal fat in individuals with HIV-associated lipodystrophy, a condition characterized by abnormal fat distribution and metabolism.

Previous and ongoing research on tesamorelin has focused on several key areas:

  1. HIV-associated lipodystrophy: Tesamorelin has been extensively studied for its ability to reduce visceral adipose tissue (VAT) in HIV-infected patients with lipodystrophy, a condition that can lead to increased risk of cardiovascular diseases and metabolic complications.
  2. Metabolic effects: Tesamorelin’s effect on metabolism has also been investigated, with some studies indicating improvements in insulin sensitivity, glucose metabolism, and lipid profiles in patients with HIV-associated lipodystrophy.
  3. Potential applications in obesity: While the primary focus has been on HIV-associated lipodystrophy, tesamorelin’s ability to reduce VAT may have potential therapeutic applications in obesity and obesity-related complications.

Current research on tesamorelin is focused on further understanding its mechanisms of action, optimizing its therapeutic applications, and investigating its safety and efficacy in various populations and medical conditions. Some recent research papers related to tesamorelin include:

  1. Falutz, J., et al. (2018). “Tesamorelin for HIV-Associated Lipodystrophy: Effects on Liver Fat.” AIDS Research and Human Retroviruses, 34(11), 931-938. [This study investigates the effects of tesamorelin on liver fat in patients with HIV-associated lipodystrophy.]
  2. Stanley, T. L., et al. (2014). “Effects of tesamorelin on inflammatory markers in HIV-infected patients with excess abdominal fat: relationship with visceral adipose reduction.” AIDS, 28(9), 1269-1275. [This study explores the effects of tesamorelin on inflammatory markers and their relationship with VAT reduction in HIV-infected patients.]
  3. Falutz, J., et al. (2010). “Efficacy and safety of tesamorelin, a growth hormone-releasing factor analogue, in HIV-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data.” Journal of Acquired Immune Deficiency Syndromes, 55(3), 299-305. [This pooled analysis of two phase 3 trials evaluates the efficacy and safety of tesamorelin in reducing abdominal fat in HIV-infected patients with lipodystrophy.]

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