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MOTS-C 5mg


MOTS-C 5mg

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a peptide encoded within the mitochondrial genome. It is a 16-amino acid peptide that has been shown to exhibit a variety of biological activities, including promoting metabolic homeostasis, increasing insulin sensitivity, and regulating cellular energy metabolism. MOTS-c has gained attention for its potential applications in the treatment of obesity, type 2 diabetes, and age-related diseases.Previous and ongoing research on MOTS-c has focused on several key areas:

  1. Metabolic regulation: MOTS-c has been shown to regulate energy metabolism by targeting skeletal muscle and enhancing insulin sensitivity. It has potential applications in the treatment of obesity and type 2 diabetes.
  2. Aging and age-related diseases: MOTS-c has been associated with the regulation of cellular processes related to aging, such as cellular senescence and mitochondrial function. It may have potential therapeutic applications in age-related diseases.
  3. Exercise and muscle function: Studies have suggested that MOTS-c may promote muscle function and improve exercise capacity, highlighting its potential role in maintaining overall health and well-being.


Current research on MOTS-c is focused on further understanding its mechanisms of action, optimizing its therapeutic applications, and investigating its safety and efficacy in various populations and medical conditions. Some recent research papers related to MOTS-c include:

  1. Lee, C., et al. (2019). “The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance.” Cell Metabolism, 29(3), 777-787. [This study investigates the role of MOTS-c in promoting metabolic homeostasis and its potential applications in obesity and insulin resistance.]
  2. Kim, S.J., et al. (2018). “The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?” Aging Cell, 17(6), e12834. [This review paper discusses the potential role of MOTS-c in longevity and age-related diseases.]
  3. Kim, K.H., et al. (2017). “MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction.” Journal of Molecular Medicine, 95(6), 623-633. [This study explores the role of MOTS-c in adipose homeostasis and its potential applications in preventing metabolic dysfunction.]
  4. Cobb, L.J., et al. (2016). “Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers.” Aging, 8(4), 796-809. [This study investigates the age-dependent roles of mitochondrial-derived peptides, including MOTS-c, in apoptosis, insulin sensitivity, and inflammation.]

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